Laura A. Lopez-Garcia

Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1

Valérie Hindie, Adriana Stroba, Hua Zhang et al. · Nature Chemical Biology · 2009 · 143 citations · Full text

Protein Kinase Pdk1, Protein Function, Signal Transduction +12

Allosteric activation of the protein kinase PDK1 with low molecular weight compounds

Matthias Engel, Valérie Hindie, Laura A. Lopez-Garcia et al. · The EMBO Journal · 2006 · 109 citations · Full text

Molecular Pharmacology, Protein Function, Signal Transduction +13

Substrate-Selective Inhibition of Protein Kinase PDK1 by Small Compounds that Bind to the PIF-Pocket Allosteric Docking Site

Katrien Busschots, Laura A. Lopez-Garcia, Carmen Lammi et al. · Chemistry & Biology · 2012 · 80 citations

Protein Kinase Pdk1, Medicinal Chemistry, Protein Function +12

3,5-Diphenylpent-2-enoic Acids as Allosteric Activators of the Protein Kinase PDK1: Structure−Activity Relationships and Thermodynamic Characterization of Binding as Paradigms for PIF-Binding Pocket-Targeting Compounds†PDB code of <b>2Z</b> with PDK1: 3HRF.

Adriana Stroba, Francis Schaeffer, Valérie Hindie et al. · Journal of Medicinal Chemistry · 2009 · 77 citations · Full text

Protein Kinase Activities, Drug Target, Atp Binding Site +18

Allosteric Regulation of Protein Kinase PKCζ by the N-Terminal C1 Domain and Small Compounds to the PIF-Pocket

Laura A. Lopez-Garcia, Jörg O. Schulze, Wolfgang Fröhner et al. · Chemistry & Biology · 2011 · 65 citations

Signal Transduction, Molecular Physiology, Allosteric Regulation +14