Clathrin-independent endocytosis of ubiquitinated cargos

Sara Sigismund, Tanja Woelk, Claudia Puri, +5

Proceedings of the National Academy of Sciences

Cellular PhysiologyEndocytic PathwayCell SignalingMolecular PhysiologyBiochemistry +14

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming

Elena Maspero, Eleonora Valentini, Sara Mari, +4

Nature Structural & Molecular Biology

Ubiquitin-loaded Hect LigaseProtein ChemistryBiochemistryNatural SciencesMolecular Biology +4

Molecular mechanisms of coupled monoubiquitination

Tanja Woelk, Barbara Oldrini, Elena Maspero, +4

Nature Cell Biology

Pattern FormationCoupled MonoubiquitinationMechanism (Biology)Molecular BiologyMulti-protein Assembly +1

Threshold-controlled ubiquitination of the EGFR directs receptor fate

Sara Sigismund, Veronica Algisi, Gilda Nappo, +12

The EMBO Journal

Threshold-controlled UbiquitinationSignal TransductionG Protein-coupled ReceptorReceptor (Biochemistry)Medicine +3

Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation

Elena Maspero, Sara Mari, Eleonora Valentini, +3

EMBO Reports

Protein FunctionProtein AssemblyNatural SciencesUbiquitin Chain ElongationMolecular Biology +5

A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase

Marco Gatti, Sabrina Pinato, Elena Maspero, +3

Cell Cycle

A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation

Yuri Frosi, Sergio Anastasi, Costanza Ballarò, +6

The Journal of Cell Biology

Kinase SuppressionSignaling PathwayCell RegulationReceptor Tyrosine KinaseAutophagy +14

Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity

Avinash K. Persaud, Sara Mari, Jiefei Tong, +6

Science Signaling

Tyrosine PhosphorylationReceptor TyrosineProtein FunctionSignal TransductionCell Regulation +13

Structural and Functional Framework for the Autoinhibition of Nedd4-Family Ubiquitin Ligases

Sara Mari, Natalia Ruétalo, Elena Maspero, +4

Structure

Protein FunctionNedd4-family Ubiquitin LigasesFunctional FrameworkProtein FoldingStructural Bioinformatics +4

Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling

Roberta Pascolutti, Veronica Algisi, Alexia Conte, +18

Cell Reports

Cell AdhesionCellular PhysiologyTumor BiologyLive Tirf MicroscopySignaling Pathway +14