Generation of quinolone antimalarials targeting the <i>Plasmodium falciparum</i> mitochondrial respiratory chain for the treatment and prophylaxis of malaria

Giancarlo A. Biagini, Nicholas Fisher, Alison E. Shone, +29

Proceedings of the National Academy of Sciences

Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs

Paul A. Stocks, Patrick G. Bray, Victoria Barton, +12

Angewandte Chemie International Edition

BiochemistryAntiparasitic AgentIron MetabolismMedicineMalaria +13

Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2)

Chandrakala Pidathala, Richard K. Amewu, Bénédicte Pacorel, +19

Journal of Medicinal Chemistry

Drug TargetPlasmodium FalciparumBiochemistryAntiparasitic AgentMedicine +12

Candidate Selection and Preclinical Evaluation of <i>N</i> - <i>tert</i> -Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century

Paul M. O’Neill, B. Kevin Park, Alison E. Shone, +21

Journal of Medicinal Chemistry

Two-Step Synthesis of Achiral Dispiro-1,2,4,5-tetraoxanes with Outstanding Antimalarial Activity, Low Toxicity, and High-Stability Profiles

Gemma L. Ellis, Richard K. Amewu, Sunil Sabbani, +15

Journal of Medicinal Chemistry

Bioorganic ChemistryAntiparasitic AgentImmunologyOrganic ChemistryChemistry +15

Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors

Edite Verissimo, Neil G. Berry, Peter Gibbons, +5

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBiochemistryMedicineNatural Sciences +6

Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2)

Suet C. Leung, Peter Gibbons, Richard K. Amewu, +19

Journal of Medicinal Chemistry

Phosphate SaltMedicinal ChemistryBioorganic ChemistryPlasmodium FalciparumBiochemistry +12

Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of <i>Mycobacterium tuberculosis</i>

W. David Hong, Peter Gibbons, Suet C. Leung, +20

Journal of Medicinal Chemistry

Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity

Peter Gibbons, Edite Verissimo, Nuna Araújo, +17

Journal of Medicinal Chemistry

Bioorganic ChemistryAntiparasitic AgentMalariaAntimicrobial ChemotherapySingle Chemical Entity +19

Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs

Paul A. Stocks, Patrick G. Bray, Victoria Barton, +12

Angewandte Chemie

Bioorganic ChemistryAntiparasitic AgentIron MetabolismMalariaVon Synthetischen Endoperoxiden +16