Jacques Briand

Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia

Melissa B. Pappalardi, Kathryn Keenan, Mark Cockerill et al. · Nature Cancer · 2021 · 251 citations · Full text

Hematological Malignancy, Medicine, Acute Myeloid Leukemia +9

Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells

Julia Billiard, Jennifer B. Dennison, Jacques Briand et al. · Cancer & Metabolism · 2013 · 231 citations · Full text

Design of potent and selective human cathepsin K inhibitors that span the active site

Scott K. Thompson, Stacie M. Halbert, Mary J. Bossard et al. · Proceedings of the National Academy of Sciences · 1997 · 119 citations · Full text

Bioorganic Chemistry, Aldo-keto Reductase, Molecular Biology +17

A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site

Mary Ann Hardwicke, Alan R. Rendina, Shawn P. Williams et al. · Nature Chemical Biology · 2014 · 103 citations · Full text

Metabolic Syndrome, Lipid Synthesis, Biochemistry +9

Development of a fully automated multichannel peptide synthesizer with an integrated TFA cleavage capability

J. Neimark, Jacques Briand · Peptides · 1994 · 91 citations

Tfa Cleavage Capability, Protein Folding, Peptide Engineering +7