Margie N. Sutton

ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7

Zhen Lü, Hailing Yang, Margie N. Sutton et al. · Cell Death and Differentiation · 2014 · 76 citations · Full text

Cell Autophagy, Mitophagy, Ras/map Signaling +10

DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters

Margie N. Sutton, Zhen Lü, Yao-Cheng Li et al. · Cell Reports · 2019 · 71 citations · Full text

Disrupting Ras Clusters, Molecular Biology, Cancer Biology +17

ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts

Michele N. Washington, Grace Suh, Aaron Orozco et al. · Cell Death and Disease · 2015 · 62 citations · Full text

Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB

Micaela Morgado, Margie N. Sutton, Mary Simmons et al. · Oncotarget · 2016 · 60 citations · Full text

RAS-related GTPases <i>DIRAS1</i> and <i>DIRAS2</i> induce autophagic cancer cell death and are required for autophagy in murine ovarian cancer cells

Margie N. Sutton, Hailing Yang, Gilbert Y. Huang et al. · Autophagy · 2018 · 56 citations · Full text

Mitophagy, Apoptosis, Immunology +18