Stephen N. Greszler

Discovery of 4-[(2 <i>R</i> ,4 <i>R</i> )-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2 <i>H</i> -chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis

Xueqing Wang, Bo Liu, Xenia B. Searle et al. · Journal of Medicinal Chemistry · 2017 · 76 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Diastereoselective Synthesis of Pentasubstituted γ‐Butyrolactones from Silyl Glyoxylates and Ketones through a Double Reformatsky Reaction

Stephen N. Greszler, Jeffrey S. Johnson · Angewandte Chemie International Edition · 2009 · 65 citations

Natural Sciences, Chemistry, Medicinal Chemistry +12

Silyl Glyoxylates. Conception and Realization of Flexible Conjunctive Reagents for Multicomponent Coupling

Gregory R. Boyce, Stephen N. Greszler, Jeffrey S. Johnson et al. · The Journal of Organic Chemistry · 2012 · 60 citations

Pharmacy, Chemistry, Medicinal Chemistry +12

Remote Stereoinduction in the Acylation of Fully Substituted Enolates: Tandem Reformatsky/Quaternary Claisen Condensations of Silyl Glyoxylates and β-Lactones

Stephen N. Greszler, Justin T. Malinowski, Jeffrey S. Johnson · Journal of the American Chemical Society · 2010 · 56 citations

Pharmacy, Chemistry, Medicinal Chemistry +16

Development of an Enantioselective [3 + 2] Cycloaddition To Synthesize the Pyrrolidine Core of ABBV-3221 on Multikilogram Scale

J. B. Hartung, Stephen N. Greszler, Russell C. Klix et al. · Organic Process Research & Development · 2019 · 42 citations

Natural Sciences, Chemistry, Catalysis +13