Markus A. Seeliger

How Does a Drug Molecule Find Its Target Binding Site?

Yibing Shan, Eric T. Kim, Michael P. Eastwood et al. · Journal of the American Chemical Society · 2011 · 650 citations

Medicine, Biophysics, Pharmacology +17

Activation of tyrosine kinases by mutation of the gatekeeper threonine

Mohammad Azam, Markus A. Seeliger, Nathanael S. Gray et al. · Nature Structural & Molecular Biology · 2008 · 416 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680

Matthew A. Young, Neil P. Shah, Luke H. Chao et al. · Cancer Research · 2006 · 277 citations

Life Sciences, Molecular Biology, Pharmacology +14

A conserved protonation-dependent switch controls drug binding in the Abl kinase

Yibing Shan, Markus A. Seeliger, Michael P. Eastwood et al. · Proceedings of the National Academy of Sciences · 2008 · 268 citations · Full text

Natural Sciences, Medicinal Chemistry, Molecular Biology +14

A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export

Ben Montpetit, N.D. Thomsen, Kara J. Helmke et al. · Nature · 2011 · 263 citations

Life Sciences, Biochemistry, Molecular Biology +16