Jesús Espada

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

Mario F. Fraga, Esteban Ballestar, Ana Villar‐Garea et al. · Nature Genetics · 2005 · 1.9K citations

Histone Modifications, Tumor Biology, Chromatin +12

Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of <b>β</b>-catenin signaling

Héctor G. Pálmer, José Manuel González‐Sancho, Jesús Espada et al. · The Journal of Cell Biology · 2001 · 796 citations · Full text

Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer

Óscar Aguilera, Mario F. Fraga, Esteban Ballestar et al. · Oncogene · 2006 · 339 citations

Wnt Antagonist Dickkopf-1, Medicine, Epigenetic Inactivation +8

Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells.

Ana Villar‐Garea, Mario F. Fraga, Jesús Espada et al. · PubMed · 2003 · 318 citations

Chemoprevention Strategy, Dna Methylation, Dna-demethylating Agent +18

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

Rubén Agrelo, Wen‐Hsing Cheng, Fernando Setién et al. · Proceedings of the National Academy of Sciences · 2006 · 262 citations · Full text

Chromatin, Werner Syndrome, Oncogenic Agent +15