Werner Rubas

A Human Colonic Cell Line Sharing Similarities With Enterocytes as a Model to Examine Oral Absorption: Advantages and Limitations of the Caco-2 Model

Florence Delié, Werner Rubas · Critical Reviews in Therapeutic Drug Carrier Systems · 1997 · 437 citations

Life Sciences, Biochemistry, Cell Biology +17

P-Glycoprotein (P-gp) Mediated Efflux in Caco-2 Cell Monolayers: The Influence of Culturing Conditions and Drug Exposure on P-gp Expression Levels

Pascale Anderle, Eva Niederer, Werner Rubas et al. · Journal of Pharmaceutical Sciences · 1998 · 230 citations

Medicine, Pharmacokinetics, Pharmacology +8

Comparison of the Permeability Characteristics of a Human Colonic Epithelial (Caco-2) Cell Line to Colon of Rabbit, Monkey, and Dog Intestine and Human Drug Absorption

Werner Rubas, Nancy Jezyk, George M. Grass · Pharmaceutical Research · 1993 · 205 citations · Full text

Pharmacy, Cell Biology, Pharmacology +15

Flux Measurements across Caco-2 Monolayers May Predict Transport in Human Large Intestinal Tissue

Werner Rubas, Mary Cromwell, Zahra Shahrokh et al. · Journal of Pharmaceutical Sciences · 1996 · 157 citations

Life Sciences, Cell Biology, Physiology +15

Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy

Deborah H. Charych, Samira Khalili, Vidula Dixit et al. · PLoS ONE · 2017 · 144 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +16