Kevin M. Wernke

Structure elucidation of colibactin and its DNA cross-links

Mengzhao Xue, Chung Sub Kim, Alan R. Healy et al. · Science · 2019 · 266 citations

Life Sciences, Biochemistry, Microbiology +16

Synthesis and reactivity of precolibactin 886

Alan R. Healy, Kevin M. Wernke, Chung Sub Kim et al. · Nature Chemistry · 2019 · 42 citations

Pharmacy, Biochemistry, Medicinal Chemistry +2

The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors

Michael W. Dougherty, Rafael Valdés‐Mas, Kevin M. Wernke et al. · Neoplasia · 2023 · 39 citations · Full text

Medicine, Genetics, Oncology +17

Depurination of Colibactin-Derived Interstrand Cross-Links

Mengzhao Xue, Kevin M. Wernke, Seth B. Herzon · Biochemistry · 2020 · 31 citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +17

Probing Microbiome Genotoxicity: A Stable Colibactin Provides Insight into Structure–Activity Relationships and Facilitates Mechanism of Action Studies

Kevin M. Wernke, Alina Tirla, Mengzhao Xue et al. · Journal of the American Chemical Society · 2021 · 19 citations

Life Sciences, Biology, Molecular Biology +13