David Whalley

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

David A. Baker, Lindsay B. Stewart, Jonathan M. Large et al. · Nature Communications · 2017 · 173 citations · Full text

Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3<i>R</i>)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-<i>b</i>]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153)

Robert H. Bradbury, Rowena Callis, Gregory R. Carr et al. · Journal of Medicinal Chemistry · 2016 · 85 citations · Full text

Pharmaceutical Science, Chemoprevention Strategy, Organic Chemistry +21

Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents

Kathryn Lougheed, Simon A. Osborne, Barbara Saxty et al. · Tuberculosis · 2011 · 79 citations · Full text

Antimicrobial Chemotherapy, Pharmaceutical Chemistry, Drug Resistance +20

Discovery of Plasmodium vivax<i>N</i>-Myristoyltransferase Inhibitors: Screening, Synthesis, and Structural Characterization of their Binding Mode

Victor Gonçalves, J.A. Brannigan, David Whalley et al. · Journal of Medicinal Chemistry · 2012 · 75 citations · Full text

Structural Characterization, Drug Target, Bioorganic Chemistry +17

Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development

Judith L. Green, Robert W. Moon, David Whalley et al. · Antimicrobial Agents and Chemotherapy · 2015 · 57 citations · Full text