Rukman R. Thota

Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors

Spencer E. Brightman, Angelica Becker, Rukman R. Thota et al. · Nature Immunology · 2023 · 69 citations · Full text

Linked CD4+/CD8+ T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression

Joseph S. Dolina, Joey Lee, Spencer E. Brightman et al. · Journal of Clinical Investigation · 2023 · 56 citations · Full text

Vaccination, Tumor Regression, Therapeutic Benefit +15

A functional identification platform reveals frequent, spontaneous neoantigen-specific T cell responses in patients with cancer

Aaron M. Miller, Zeynep Koşaloğlu, Luise Westernberg et al. · Science Translational Medicine · 2024 · 18 citations

Tumor cells fail to present MHC-II–restricted epitopes derived from oncogenes to CD4+ T cells

Spencer E. Brightman, Martin S. Naradikian, Rukman R. Thota et al. · JCI Insight · 2022 · 15 citations · Full text