Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes

Meiqin Hu, Ping Li, Ce Wang, +11

Cell

Proton-activated Proton ChannelProtein FunctionDisease-risk Protein Tmem175Natural SciencesAutophagy +7

Critical role of TRPC6 channels in the formation of excitatory synapses

Jian Zhou, Wanlu Du, Kechun Zhou, +5

Nature Neuroscience

Synaptic PlasticityTrpc6 ChannelsSignal TransductionMolecular PhysiologyNeurophysiology +9

TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway

Yilin Tai, Shengjie Feng, Ruiliang Ge, +4

Journal of Cell Science

Trpc6 ChannelsSignal TransductionMolecular PhysiologyDevelopmental BiologySignaling Pathway +11

Inhibition of TRPC6 degradation suppresses ischemic brain damage in rats

Wanlu Du, Junbo Huang, Hailan Yao, +3

Journal of Clinical Investigation

Stem cell-released oncolytic herpes simplex virus has therapeutic efficacy in brain metastatic melanomas

Wanlu Du, Ivan Seah, Oumaima Bougazzoul, +6

Proceedings of the National Academy of Sciences

Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma

Wanlu Du, Mingxue Gu, Meiqin Hu, +6

Cell Reports

<scp>TRPC</scp>6 inhibited <scp>NMDA</scp> receptor activities and protected neurons from ischemic excitotoxicity

Hongyu Li, Junbo Huang, Wanlu Du, +3

Journal of Neurochemistry

Ischemic ExcitotoxicityCell DeathTrpc6 TransgenicCellular PhysiologySocial Sciences +18

CRISPR-enhanced engineering of therapy-sensitive cancer cells for self-targeting of primary and metastatic tumors

Clemens Reinshagen, Deepak Bhere, Sung Hugh Choi, +8

Science Translational Medicine

Targeting breast to brain metastatic tumours with death receptor ligand expressing therapeutic stem cells

Tugba Bagcı-Önder, Wanlu Du, José Luiz de Figueiredo, +2

Brain

Anti-EGFR VHH-armed death receptor ligand–engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers

Yohei Kitamura, Nobuhiko Kanaya, Susana Moleirinho, +12

Science Advances