Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO)

Wu He, Bin Zhou, Weijia Liu, +16

Journal of Medicinal Chemistry

Crystal StructureDrug TargetProtein AssemblyMolecular BiologyChemical Biology +19

Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis

Xinshou Ouyang, Shengna Han, Jiyuan Zhang, +20

Cell Metabolism

InflammationRedox SignalingBiochemistryRedox RegulatorMedicine +6

Fluconazole inhibits hERG K+ channel by direct block and disruption of protein trafficking

Shengna Han, Yu Zhang, Chen Qiu, +5

European Journal of Pharmacology

Signal TransductionBiochemistryMedicineProtein TraffickingK+ Channel +7

GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation

Suyavaran Arumugam, Yanqin Qin, Ziwen Liang, +7

Cell Death and Differentiation

Signal TransductionSignaling PathwayCell SignalingCell InteractionNlrp3 Inflammasome Activation +5

GSK-3β-mediated activation of NLRP3 inflammasome leads to pyroptosis and apoptosis of rat cardiomyocytes and fibroblasts

Shuhui Wang, Liu-Gen Cui, Xue-Ling Su, +5

European Journal of Pharmacology

InflammationSignal TransductionSignaling PathwayMedicineNecroptosis +13

Lamin A mutation impairs interaction with nucleoporin NUP155 and disrupts nucleocytoplasmic transport in atrial fibrillation

Meng Han, Miao Zhao, Cheng Chen, +11

Human Mutation

The HNF1α-Regulated LncRNA HNF1α-AS1 Is Involved in the Regulation of Cytochrome P450 Expression in Human Liver Tissues and Huh7 Cells

Yi‐Ting Wang, Yan Liang, Jingyang Liu, +9

Journal of Pharmacology and Experimental Therapeutics

Activation of NLRP3 inflammasome promotes the proliferation and migration of esophageal squamous cell carcinoma

Shuang Yu, Jianjian Yin, Jinxin Miao, +8

Oncology Reports

Esophageal CancerImmunologyImmune RegulationCell DeathPathology +17

Inulin with a low degree of polymerization protects human umbilical vein endothelial cells from hypoxia/reoxygenation-induced injury

Xuexiang Cha, Shengna Han, Jian Yu, +6

Carbohydrate Polymers

AngiogenesisVascular AdaptationHypoxia/reoxygenation-induced InjuryExtracellular MatrixEndothelial Dysfunction +7

Glycogen synthase kinase-3β inhibition alleviates activation of the NLRP3 inflammasome in myocardial infarction

Shuhui Wang, Xue-Ling Su, Lina Xu, +8

Journal of Molecular and Cellular Cardiology

InflammationKinase-3β InhibitionCardiovascular DiseaseNlrp3 InflammasomeImmunology +11