Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic colorectal cancer in mice

Manuela González-Aparicio, Pilar Alzuguren, Itsaso Mauleón, +8

Gut

Effect of Adeno-Associated Virus Serotype and Genomic Structure on Liver Transduction and Biodistribution in Mice of Both Genders

Astrid Pañeda, Lucía Vanrell, Itsaso Mauleón, +10

Human Gene Therapy

GeneticsImmunologyPathologyLiver TransductionAav Genomes +14

Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates

Carmen Unzu, Sandra Hervás‐Stubbs, Ana Sampedro, +10

Journal of Translational Medicine

Sustained Enzymatic Correction by rAAV-Mediated Liver Gene Therapy Protects Against Induced Motor Neuropathy in Acute Porphyria Mice

Carmen Unzu, Ana Sampedro, Itsaso Mauleón, +11

Molecular Therapy

MYC in Chronic Myeloid Leukemia: Induction of Aberrant DNA Synthesis and Association with Poor Response to Imatinib

Marta Albajar, María Teresa Gómez‐Casares, Javier Llorca, +7

Molecular Cancer Research

Safety and Liver Transduction Efficacy of rAAV5- <i>cohPBGD</i> in Nonhuman Primates: A Potential Therapy for Acute Intermittent Porphyria

Astrid Pañeda, Esperanza López‐Franco, Christine Kaeppel, +20

Human Gene Therapy

Myc Antagonizes Ras-mediated Growth Arrest in Leukemia Cells through the Inhibition of the Ras-ERK-p21Cip1 Pathway

José P. Vaqué, Joaquin Navascues, Yuzuru Shiio, +6

Journal of Biological Chemistry

Intrahepatic injection of adenovirus reduces inflammation and increases gene transfer and therapeutic effect in mice

Julien Crettaz, Pedro Berraondo, Itsaso Mauleón, +9

Hepatology

InflammationIntrahepatic InjectionTherapeutic EffectHepatologyLiver Physiology +13

Porphobilinogen deaminase over-expression in hepatocytes, but not in erythrocytes, prevents accumulation of toxic porphyrin precursors in a mouse model of acute intermittent porphyria

Carmen Unzu, Ana Sampedro, Itsaso Mauleón, +7

Journal of Hepatology

Toxic Porphyrin PrecursorsMedicineLiver PhysiologyPhysiologyExperimental Toxicology +12

Intensive Pharmacological Immunosuppression Allows for Repetitive Liver Gene Transfer With Recombinant Adenovirus in Nonhuman Primates

Antonio Fontanellas, Sandra Hervás‐Stubbs, Itsaso Mauleón, +12

Molecular Therapy