James P. Lajiness

Divergent Total Syntheses of (−)-Aspidospermine and (+)-Spegazzinine

James P. Lajiness, Wanlong Jiang, Dale L. Boger · Organic Letters · 2012 · 60 citations · Full text

Design, Synthesis, and Evaluation of Duocarmycin <i>O</i>-Amino Phenol Prodrugs Subject to Tunable Reductive Activation

James P. Lajiness, W. M. Robertson, Irene Dunwiddie et al. · Journal of Medicinal Chemistry · 2010 · 32 citations · Full text

Asymmetric Synthesis of 1,2,9,9a-Tetrahydrocyclopropa[<i>c</i>]benzo[<i>e</i>]indol-4-one (CBI)

James P. Lajiness, Dale L. Boger · The Journal of Organic Chemistry · 2010 · 28 citations · Full text

Diversity Oriented Synthesis, Engineering, Heterocyclic +14

A Fundamental Relationship between Hydrophobic Properties and Biological Activity for the Duocarmycin Class of DNA-Alkylating Antitumor Drugs: Hydrophobic-Binding-Driven Bonding

Amanda L. Wolfe, Katharine K. Duncan, James P. Lajiness et al. · Journal of Medicinal Chemistry · 2013 · 18 citations · Full text

Sequence specific and high affinity recognition of 5′-ACGCGT-3′ by rationally designed pyrrole-imidazole H-pin polyamides: Thermodynamic and structural studies

Hilary Mackay, Toni Brown, Peter B. Uthe et al. · Bioorganic & Medicinal Chemistry · 2008 · 16 citations · Full text

Pyrrole-imidazole H-pin Polyamides, Engineering, High Affinity Recognition +8