An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

Michael Schoof, Bryan Faust, Reuben A. Saunders, +143

Science

Materials ScienceTrivalent NanobodySpike ProteinEngineeringNanotechnology +8

Cryo-EM structures of the TMEM16A calcium-activated chloride channel

Shangyu Dang, Shengjie Feng, Jason Tien, +13

Nature

EngineeringMembrane TransportCryogenicsCryo-em StructuresIon Channels +4

Revisiting the structures of several antibiotics bound to the bacterial ribosome

David Bulkley, C.A. Innis, Gregor Blaha, +1

Proceedings of the National Academy of Sciences

Electron DensitySeveral AntibioticsProkaryotic SystemAntibioticsBiomolecular Structure Prediction +13

Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix

Jessica A. Brown, David Bulkley, Jimin Wang, +4

Nature Structural & Molecular Biology

ChromatinSystems BiologyMedicineNatural SciencesRna Structure Prediction +6

The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs

Peter Shen, Xiaoyong Yang, Paul G. DeCaen, +4

Cell

Proteinlipid InteractionMolecular PhysiologyLipid NanodiscsBiochemistryKidney Research +5

Electron cryo-microscopy structure of the mechanotransduction channel NOMPC

Peng Jin, David Bulkley, Yanmeng Guo, +9

Nature

Mechanotransduction Channel NompcElectron MicroscopyMicroscopyCryogenicsElectron Microscope +3

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched

Yunxiao Zhang, David Bulkley, Yao Xin, +7

Cell

Proteinlipid InteractionMolecular PhysiologySignal TransductionBiochemistryOxysterol +10

A simple and robust procedure for preparing graphene-oxide cryo-EM grids

Eugene Palovcak, Feng Wang, Shawn Zheng, +6

Journal of Structural Biology

Materials ScienceGraphene NanomeshesGraphene-based Nano-antennasEngineeringRobust Procedure +5

Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation

Jinzhong Lin, Matthieu G. Gagnon, David Bulkley, +1

Cell

Protein FoldingTrna TranslocationProtein BiosynthesisRna Structure PredictionMolecular Biology +6

Structural Basis for the Rescue of Stalled Ribosomes: Structure of YaeJ Bound to the Ribosome

Matthieu G. Gagnon, S.V. Seetharaman, David Bulkley, +1

Science

Protein AssemblyProtein FoldingNatural SciencesProtein BiosynthesisRna Structure Prediction +12