Willem-Jan F. Karstens

Identification of Substituted 6-Amino-4-phenyltetrahydroquinoline Derivatives:  Potent Antagonists for the Follicle-Stimulating Hormone Receptor

Nicole C.R. van Straten, Twan H. J. van Berkel, Dennis Demont et al. · Journal of Medicinal Chemistry · 2004 · 81 citations · Full text

Signaling of an allosteric, nanomolar potent, low molecular weight agonist for the follicle-stimulating hormone receptor

Chris J. van Koppen, P. M. Verbost, Ruud van de Lagemaat et al. · Biochemical Pharmacology · 2013 · 51 citations

Molecular Pharmacology, Molecular Physiology, Signal Transduction +13

Mechanism of action of a nanomolar potent, allosteric antagonist of the thyroid‐stimulating hormone receptor

Chris J. van Koppen, Marcel E. de Gooyer, Willem-Jan F. Karstens et al. · British Journal of Pharmacology · 2011 · 46 citations · Full text

Complete Inhibition of rhTSH-, Graves' Disease IgG-, and M22-Induced cAMP Production in Differentiated Orbital Fibroblasts by a Low-Molecular-Weight TSHR Antagonist

Clementine J.J. van Zeijl, Chris J. van Koppen, Olga V. Surovtseva et al. · The Journal of Clinical Endocrinology & Metabolism · 2012 · 39 citations · Full text

Immunology, Immunologic Mechanism, Pharmacotherapy +19

Multidimensional Profiling of CSF1R Screening Hits and Inhibitors: Assessing Cellular Activity, Target Residence Time, and Selectivity in a Higher Throughput Way

Joost C.M. Uitdehaag, Cecile M. Sünnen, Antoon M. van Doornmalen et al. · SLAS DISCOVERY · 2011 · 20 citations · Full text

Drug Target, Hit Identification, Multidimensional Profiling +19