A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer

Shi Jiao, Huizhen Wang, Zhubing Shi, +14

Cancer Cell

Signal TransductionG Protein-coupled ReceptorMedicineYap Antagonist TherapyPeptide Therapeutic +7

The tethered peptide activation mechanism of adhesion GPCRs

Ximena Barros-Álvarez, Robert M. Nwokonko, Alexander Vizurraga, +14

Nature

Adhesion GpcrsCell AdhesionAdhesive MaterialMedicineBiophysics

A Potent, Selective and Cell‐Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)

H. Ümit Kanıskan, Magdalena M. Szewczyk, Zhengtian Yu, +25

Angewandte Chemie International Edition

Structure determination of inactive-state GPCRs with a universal nanobody

Michael J. Robertson, Makaía M. Papasergi-Scott, Feng He, +6

Nature Structural & Molecular Biology

Materials ScienceEngineeringNanomaterialsNanotechnologyUniversal Nanobody +1

Rescue Screens with Secreted Proteins Reveal Compensatory Potential of Receptor Tyrosine Kinases in Driving Cancer Growth

Fred Harbinski, Vanessa J. Craig, Sneha Sanghavi, +19

Cancer Discovery

Drug TargetRescue ScreensKinase InhibitorsCancer BiologyActive Rtks +16

Time-resolved cryo-EM of G-protein activation by a GPCR

Makaía M. Papasergi-Scott, Guillermo Pérez‐Hernández, Hossein Batebi, +12

Nature

Protein ChemistryG Protein-coupled ReceptorNatural SciencesG-protein ActivationMolecular Biology +1

DNA-binding mechanism of the Hippo pathway transcription factor TEAD4

Zhubing Shi, Feng He, Mei Chen, +4

Oncogene

Transcriptional RegulationDna-binding MechanismGeneticsGene RegulationGene Expression +3

Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor

Feng He, Cheng-Guo Wu, Yang Gao, +9

Nature

Molecular PhysiologySignal TransductionBiochemistryG Protein-coupled ReceptorMedicine +5

Striatins Contain a Noncanonical Coiled Coil That Binds Protein Phosphatase 2A A Subunit to Form a 2:2 Heterotetrameric Core of Striatin-interacting Phosphatase and Kinase (STRIPAK) Complex

Cuicui Chen, Zhubing Shi, Wenqing Zhang, +10

Journal of Biological Chemistry

Structural Insights into Mitochondrial Antiviral Signaling Protein (MAVS)-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Signaling

Zhubing Shi, Zhen Zhang, Zhenzhen Zhang, +8

Journal of Biological Chemistry