Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver

Pushpa Hegde, Emmanuel Weiss, Valérie Paradis, +16

Nature Communications

Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity

Héloïse Flament, Matthieu Rouland, Lucie Beaudoin, +31

Nature Immunology

Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity

Élise Dalmas, Amine Toubal, Fawaz Alzaïd, +23

Nature Medicine

InflammationMetabolic SyndromeObesityInsulin SensitivitySignal Transduction +13

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

Amine Toubal, Badr Kiaf, Lucie Beaudoin, +12

Nature Communications

Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes

Rongrong Fan, Amine Toubal, Saioa Goñi, +15

Nature Medicine

ObesityMetabolic SyndromeInflammationCo-repressor Gps2Signal Transduction +12

SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation

Amine Toubal, Karine Clément, Rongrong Fan, +7

Journal of Clinical Investigation

GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation

Karima Drareni, Raphaëlle Ballaire, Serena Barilla, +14

Cell Reports

Prospective head-to-head comparison of non-invasive scores for diagnosis of fibrotic MASH in patients with type 2 diabetes

Laurent Castéra, Philippe Garteiser, Cédric Laouenan, +86

Journal of Hepatology

Non-invasive ScoresDiabetesType 2DiagnosisBlood Glucose Monitoring +4

Outcome of SARS-CoV-2 infection linked to MAIT cell activation and cytotoxicity: evidence for an IL-18 dependent mechanism

Héloïse Flament, Matthieu Rouland, Lucie Beaudoin, +22

ImmunologyImmune RegulationMait CellsImmunologic MechanismCd4 T Cell Responses +22