Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface

Yosuke Toyoda, Kazushi Morimoto, Ryoji Suno, +30

Nature Chemical Biology

Proteinlipid InteractionSignal TransductionLipid-bilayer InterfaceBiochemistryG Protein-coupled Receptor +5

Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode

Yuki Shiimura, Shoichiro Horita, Akie Hamamoto, +8

Nature Communications

Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone

Dohyun Im, Asuka Inoue, Takaaki Fujiwara, +16

Nature Communications

Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog

Hidetsugu Asada, Shoichiro Horita, Kunio Hirata, +11

Nature Structural & Molecular Biology

Molecular PharmacologyCrystal StructureAngiotensin Ii AnalogReceptor BoundBiochemistry +9

The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone

Hidetsugu Asada, Asuka Inoue, Francois Marie Ngako Kadji, +13

Structure

Molecular PharmacologyCrystal StructureBiochemistryMedicineReceptor (Biochemistry) +6

Endogenous agonist–bound S1PR3 structure reveals determinants of G protein–subtype bias

Shintaro Maeda, Yuki Shiimura, Hidetsugu Asada, +9

Science Advances

Crystal StructureGeneticsMolecular BiologyMolecular PharmacologySignaling Pathway +14

A µ-opioid receptor modulator that works cooperatively with naloxone

Evan S. O’Brien, Vipin Ashok Rangari, Amal El Daibani, +16

Nature

Molecular Pharmacologyµ-Opioid Receptor ModulatorAddictionMedicineBehavioral Pharmacology +7

FABP3 and brown adipocyte-characteristic mitochondrial fatty acid oxidation enzymes are induced in beige cells in a different pathway from UCP1

Yuki Nakamura, Takahiro Sato, Yuki Shiimura, +2

Biochemical and Biophysical Research Communications

MitophagyMitochondrial FunctionBiochemistryBeige CellsAutophagy +7

A cryptic pocket in CB1 drives peripheral and functional selectivity

Vipin Ashok Rangari, Evan S. O’Brien, Alexander S. Powers, +25

Nature

I-mfa domain proteins specifically interact with SERTA domain proteins and repress their transactivating functions

Shuichi Kusano, Yuki Shiimura

Biochimie

Serta Domain ProteinsProtein FunctionSignal TransductionSignaling PathwayProtein Expression +10