The Actin-Severing Protein Cofilin Is Downstream of Neuregulin Signaling and Is Essential For Schwann Cell Myelination

Nicklaus A. Sparrow, Maria Elisa Manetti, Marga Bott, +6

Journal of Neuroscience

Neuregulin and laminin stimulate phosphorylation of the NF2 tumor suppressor in Schwann cells by distinct protein kinase A and p21-activated kinase-dependent pathways

Courtney Thaxton, Jorge Lopera, Marga Bott, +1

Oncogene

Cancer ResearchSignal TransductionReceptor Tyrosine KinaseSchwann CellsNf2 Tumor Suppressor +7

A chemical biology approach identified PI3K as a potential therapeutic target for neurofibromatosis type 2.

Alejandra M. Petrilli, Marisa A. Fuse, Mathew S Donnan, +9

PubMed

Chemoprevention StrategyPathologyGliomaTumor BiologyNeuroinflammation +18

Ponatinib promotes a G1 cell-cycle arrest of merlin/NF2-deficient human schwann cells

Alejandra M. Petrilli, Jeanine Garcia, Marga Bott, +12

Oncotarget

Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2

Robert J. Allaway, Steven P. Angus, Roberta L. Beauchamp, +28

PLoS ONE

EngineeringPathologyGliomaTumor BiologyNeuro-oncology +14

Schwannomin/merlin promotes Schwann cell elongation and influences myelin segment length

Courtney Thaxton, Marga Bott, Barbara J. Walker, +3

Molecular and Cellular Neuroscience

NeuroregenerationMolecular NeuroscienceDevelopmental BiologyNeuroanatomyMedicine +6

Phosphorylation of the NF2 tumor suppressor in Schwann cells is mediated by Cdc42-Pak and requires paxillin binding

Courtney Thaxton, Jorge Lopera, Marga Bott, +3

Molecular and Cellular Neuroscience

Tumor BiologySignal TransductionSignaling PathwayCell RegulationPaxillin Binding +9

Serum and forskolin cooperate to promote G1 progression in Schwann cells by differentially regulating cyclin D1, cyclin E1, and p27^Kip expression

Jared Iacovelli, Jorge Lopera, Marga Bott, +4

Glia

Node of Ranvier formation on motoneurons in vitro

John W. Rumsey, Mainak Das, Maria Stancescu, +3

Biomaterials

Molecular PhysiologyCell MotilityCytoskeletonRanvier FormationNervous System +4

ATP stimulated catecholamine secretion: Response in perfused adrenal glands and a subpopulation of cultured chromaffin cells

Lih Fang Lin, Marga Bott, Lung‐Sen Kao, +1

Neuroscience Letters

Adrenal GlandMolecular PhysiologyPituitary GlandBiochemistryEndocrine Mechanism +11