Helene Chaignot

The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain

Gerard M.P. Giblin, Rino A. Bit, Susan H. Brown et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 47 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Pyrrolidine-5,5-<i>trans</i>-lactams. 1. Synthesis and Incorporation into Inhibitors of Hepatitis C Virus NS3/4A Protease

David Andrews, Seb J. Carey, Helene Chaignot et al. · Organic Letters · 2002 · 26 citations

Pharmacy, Chemistry, Medicinal Chemistry +15

Discovery of novel biaryl heterocyclic EP1 receptor antagonists

Adrian Hall, Rino A. Bit, Susan H. Brown et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 21 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

The design of potent, non-peptidic inhibitors of hepatitis C protease

David Andrews, Helene Chaignot, Barry A. Coomber et al. · European Journal of Medicinal Chemistry · 2003 · 18 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Design and synthesis of ethyl pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease

Martin J. Slater, David Andrews, Graham R. Baker et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 17 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13