Subra Kugathasan

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

Dirk Gevers, Subra Kugathasan, Lee A. Denson et al. · Cell Host & Microbe · 2014 · 3.2K citations · Full text

Chronic Inflammatory Diseases, Dysbiosis, Mucosal Immunology +7

A genomic mutational constraint map using variation in 76,156 human genomes

Siwei Chen, Laurent C. Francioli, Julia K. Goodrich et al. · Nature · 2023 · 1.1K citations · Full text

Medicine, Genetics, Evolutionary Biology +8

Induction and Maintenance Infliximab Therapy for the Treatment of Moderate-to-Severe Crohn’s Disease in Children

Jeffrey S. Hyams, Wallace Crandall, Subra Kugathasan et al. · Gastroenterology · 2006 · 859 citations

Inflammation, Childhood Arthritis, Gastroenterology +5

Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy

Jérôme C. Martin, Christie Chang, Gilles Boschetti et al. · Cell · 2019 · 850 citations · Full text

Inflammation, Chronic Inflammatory Diseases, Anti-tnf Therapy +12

A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients

A. Brantley Hall, Moran Yassour, Jenny Sauk et al. · Genome Medicine · 2017 · 736 citations · Full text