Jonathan D. Wren

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu, Tamar Tchkonia, Tamar Pirtskhalava et al. · Aging Cell · 2015 · 2.4K citations · Full text

Life Sciences, Cell Biology, Pharmacology +17

Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

Yi Zhu, Tamar Tchkonia, Heike Fuhrmann‐Stroissnigg et al. · Aging Cell · 2015 · 1.1K citations · Full text

Medicine, Molecular Medicine, Pharmacology +16

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

Christopher J. Lessard, He Li, Indra Adrianto et al. · Nature Genetics · 2013 · 522 citations · Full text

Life Sciences, Genetics, Immunology +14

Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naïve CD4+ T cells from lupus patients

Patrick Coit, Matlock A. Jeffries, Nezam Altorok et al. · Journal of Autoimmunity · 2013 · 310 citations · Full text

Life Sciences, Genetics, Immunology +16

High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry

Celi Sun, Julio E. Molineros, Loren L. Looger et al. · Nature Genetics · 2016 · 268 citations · Full text

Life Sciences, Genetics, Immunology +14