Christopher D. Beadle

The Role of Myosin II in Glioma Invasion of the Brain

Christopher D. Beadle, Marcela C. Assanah, Pascale Monzo et al. · Molecular Biology of the Cell · 2008 · 315 citations · Full text

Medicine, Neuroscience, Oncology +13

Direct inhibition of myosin II effectively blocks glioma invasion in the presence of multiple motogens

Sanja Ivković, Christopher D. Beadle, Sonal S. Noticewala et al. · Molecular Biology of the Cell · 2012 · 98 citations · Full text

Medicine, Cancer Biology, Oncology +17

Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1<i>S</i>,2<i>S</i>,5<i>R</i>,6<i>S</i>-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures

James A. Monn, Lourdes Prieto, Lorena Taboada et al. · Journal of Medicinal Chemistry · 2015 · 61 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Synthesis and Pharmacological Characterization of <i>C</i>4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1<i>R</i>,2<i>S</i>,4<i>R</i>,5<i>R</i>,6<i>R</i>)-2-Amino-4-(1<i>H</i>-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu₂ Receptor Agonist

James A. Monn, Lourdes Prieto, Lorena Taboada et al. · Journal of Medicinal Chemistry · 2015 · 57 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1<i>S</i>,3<i>R</i>)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1<i>H</i>)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor

Junliang Hao, James P. Beck, John M. Schaus et al. · Journal of Medicinal Chemistry · 2019 · 56 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17