T. Shaw

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

Andrew J. Massey, D.S. Williamson, Helen Browne et al. · Cancer Chemotherapy and Pharmacology · 2009 · 329 citations · Full text

Medicine, Oncology, Pharmacology +16

Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered Through Structure-Based Design

D.S. Williamson, Jenifer Borgognoni, Alexandra Clay et al. · Journal of Medicinal Chemistry · 2009 · 229 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity

Alba T. Macias, D.S. Williamson, Nicola J. Allen et al. · Journal of Medicinal Chemistry · 2011 · 114 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)

D.S. Williamson, Garrick P. Smith, P. Acheson-Dossang et al. · Journal of Medicinal Chemistry · 2017 · 47 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase

Paul A. Brough, Lisa Baker, Simon T. Bedford et al. · Journal of Medicinal Chemistry · 2017 · 38 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +13