Chao Yao

Discovery of 4-((7<i>H</i>-Pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino)-<i>N</i>-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1<i>H</i>-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia

Yue Wang, Yanle Zhi, Qiaomei Jin et al. · Journal of Medicinal Chemistry · 2018 · 123 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells

Zihang Xu, Fei Zhang, Chao Bai et al. · Journal of Experimental & Clinical Cancer Research · 2017 · 111 citations · Full text

Medicine, Oncology, Pharmacology +17

KIAA1199 promotes sorafenib tolerance and the metastasis of hepatocellular carcinoma by activating the EGF/EGFR-dependent epithelial-mesenchymal transition program

Yanmin Xu, Huailong Xu, Mingyuan Li et al. · Cancer Letters · 2019 · 61 citations

Medicine, Cancer Biology, Oncology +16

Myocardial caspase-3 and NF-κB activation promotes calpain-induced septic apoptosis: The role of Akt/eNOS/NO pathway

Rong Luo, Xuepin Chen, Huihui Ma et al. · Life Sciences · 2019 · 31 citations

Life Sciences, Cardiology, Cell Biology +17

Stereoselective Synthesis of Functionalized Benzooxazepino[5,4-<i>a</i>]isoindolone Derivatives via Cesium Carbonate Catalyzed Formal [5 + 2] Annulation of 2-(2-Hydroxyphenyl)isoindoline-1,3-dione with Allenoates

Chao Yao, Yishu Bao, Tao Lu et al. · Organic Letters · 2018 · 27 citations

Natural Sciences, Chemistry, Medicinal Chemistry +14