Yanle Zhi

Discovery of 4-((7<i>H</i>-Pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino)-<i>N</i>-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1<i>H</i>-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia

Yue Wang, Yanle Zhi, Qiaomei Jin et al. · Journal of Medicinal Chemistry · 2018 · 123 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Discovery of Benzo[<i>cd</i>]indol-2(1<i>H</i>)-ones and Pyrrolo[4,3,2-<i>de</i>]quinolin-2(1<i>H</i>)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis

Fei Jiang, Qinghua Hu, Zhimin Zhang et al. · Journal of Medicinal Chemistry · 2019 · 69 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors

Zhimin Zhang, Shaohua Hou, Hongli Chen et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 59 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Rhodium-Catalyzed Asymmetric Conjugate Alkynylation of β,γ-Unsaturated α-Ketoesters

Yanle Zhi, Jianhang Huang, Na Liu et al. · Organic Letters · 2017 · 38 citations

Natural Sciences, Chemistry, Catalysis +11

Rhodium(I)‐Catalyzed Arylation/Dehydroxylation of <i>tert</i>‐Propargylic Alcohols Leading to Tetrasubstituted Allenes

Na Liu, Yanle Zhi, Jian Yao et al. · Advanced Synthesis & Catalysis · 2017 · 27 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9