The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer’s Disease

Henrik H. Hansen, Katrine Fabricius, Pernille Barkholt, +7

Journal of Alzheimer s Disease

Geriatric PsychiatryAgingNeurochemical BiomarkersAlzheimer ’Social Sciences +18

A genetic map of the mouse dorsal vagal complex and its role in obesity

Mette Q. Ludwig, Wenwen Cheng, Desiree Gordian, +11

Nature Metabolism

BiologyKnockout MouseDevelopmental BiologyMolecular PhysiologyGenetic Map +9

The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy

Henrik H. Hansen, Pernille Barkholt, Katrine Fabricius, +5

Brain Research

Knockout MouseSignal TransductionMolecular PhysiologyMedicinePhysiology +6

Long-term polarization of microglia upon α-synuclein overexpression in nonhuman primates

Pernille Barkholt, Vanesa Sánchez-Guajardo, Deniz Kirik, +1

Neuroscience

Neurodegenerative DiseasesMolecular NeuroscienceCellular NeuroscienceMedicineImmunology +10

An Optimized Mouse Brain Atlas for Automated Mapping and Quantification of Neuronal Activity Using iDISCO+ and Light Sheet Fluorescence Microscopy

Johanna Perens, Casper Gravesen Salinas, Jacob Lercke Skytte, +8

Neuroinformatics

EngineeringAutomated MappingBrain MappingMouse BrainsTissue Imaging +19

Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model

Lone Helboe, Jan Egebjerg, Pernille Barkholt, +1

Brain Research

Neurodegenerative DiseasesCa1 NeuronsDegenerative PathologyDegenerative DiseaseMouse Tauopathy Model +6

Whole-brain activation signatures of weight-lowering drugs

Henrik H. Hansen, Johanna Perens, Urmas Roostalu, +8

Molecular Metabolism

Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease

Henrik H. Hansen, Katrine Fabricius, Pernille Barkholt, +8

PLoS ONE

Transgenic Mouse ModelsNeurochemical BiomarkersSynaptic SignalingAlzheimer's DiseaseExtracellular β-Amyloid Peptides +18

Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease

Urmas Roostalu, Casper Bo Gravesen Salinas, Ditte Dencker Thorbek, +10

Disease Models & Mechanisms

The endogenous preproglucagon system is not essential for gut growth homeostasis in mice

Pernille Wismann, Pernille Barkholt, Thomas Secher, +8

Molecular Metabolism