Regulation of autophagy by ATF4 in response to severe hypoxia

Tomasz Rzymski, Massimo Milani, Luke Pike, +6

Oncogene

InflammationCell AutophagyMitophagyRedox RegulatorPhysiology +8

The Role of ATF4 Stabilization and Autophagy in Resistance of Breast Cancer Cells Treated with Bortezomib

Manuela Milani, Tomasz Rzymski, Howard R. Mellor, +4

Cancer Research

Breast OncologyCell DeathAtf4 StabilizationEndoplasmic Reticulum StressCancer Biology +15

SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains

Tomasz Rzymski, Michał Mikuła, Eliza Żyłkiewicz, +25

Oncotarget

ImmunologyLineage CommitmentCancer BiologyTumor BiologyTranscriptional Regulation +15

Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3

Hilda Mujčić, Tomasz Rzymski, Kasper M.A. Rouschop, +4

Radiotherapy and Oncology

Hypoxic ActivationMetastasis-associated Gene Lamp3Cell RegulationHypoxia (Medicine)Unfolded Protein Response +5

MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma

Zhan Yao, Jun Guo, William Yang, +23

Journal of Clinical Investigation

Transcriptional RegulationSignal TransductionCell RegulationMedicineReceptor Tyrosine Kinase +13

The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress

Tomasz Rzymski, Andreas Petry, Damir Kračun, +4

Oncogene

Reductive StressPhysiologyHypoxia (Medicine)Unfolded Protein ResponseEr Stress +6

The Caenorhabditis elegans ortholog of human PHF5a shows a muscle-specific expression domain and is essential for C. elegans morphogenetic development

Ralf Ulrich Trappe, Ekkehard Schulze, Tomasz Rzymski, +2

Biochemical and Biophysical Research Communications

Developmental BiologySignaling PathwayDevelopmental GeneticsMuscle-specific Expression DomainMorphogenesis +7

An oncogenic role of eIF3e/INT6 in human breast cancer

Michal Grzmil, Tomasz Rzymski, Massimo Milani, +6

Oncogene

Oncogenic RoleBreast OncologyMedicineBreast CancerCancer Biology +3

Serine Biosynthesis Pathway Supports MYC–miR-494–EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells

Emilia Białopiotrowicz, Monika Noyszewska‐Kania, Neli Kachamakova‐Trojanowska, +25

Cancers

Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses

Fan Huang, Christophe Gonçalves, Margarita Bartish, +30

Journal of Clinical Investigation

ImmunologyMnk1/2-eif4e Axis ImpairsImmune Cell TherapyImmunotherapyTumor Biology +17