Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3

Nathaniel Robichaud, Sonia V. del Rincón, Bonnie Huor, +11

Oncogene

Eif4e Promotes EmtSignal TransductionDevelopmental BiologySignaling PathwayCell Regulation +8

MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma

Zhan Yao, Jun Guo, William Yang, +23

Journal of Clinical Investigation

Transcriptional RegulationSignal TransductionCell RegulationMedicineReceptor Tyrosine Kinase +13

Use of allostery to identify inhibitors of calmodulin-induced activation of <i>Bacillus anthracis</i> edema factor

Élodie Laine, Christophe Gonçalves, Johanna C. Karst, +6

Proceedings of the National Academy of Sciences

Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses

Fan Huang, Christophe Gonçalves, Margarita Bartish, +30

Journal of Clinical Investigation

ImmunologyMnk1/2-eif4e Axis ImpairsImmune Cell TherapyImmunotherapyTumor Biology +17

Peroxisomes protect lymphoma cells from HDAC inhibitor-mediated apoptosis

Michael S. Dahabieh, Zongyi Ha, Erminia Di Pietro, +9

Cell Death and Differentiation

InflammationRedox RegulatorMedicineLymphoma CellsApoptosis +11

The MNK1/2–eIF4E Axis Supports Immune Suppression and Metastasis in Postpartum Breast Cancer

Qianyu Guo, Margarita Bartish, Christophe Gonçalves, +31

Cancer Research

Morbillivirus Control of the Interferon Response: Relevance of STAT2 and mda5 but Not STAT1 for Canine Distemper Virus Virulence in Ferrets

Nicholas Svitek, Ingo Gerhauser, Christophe Gonçalves, +6

Journal of Virology

MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma <i>In Situ</i>

Qianyu Guo, Vivian Z. Li, Jessica N. Nichol, +26

Cancer Research

MNK2 governs the macrophage antiinflammatory phenotype

Margarita Bartish, Dongmei Tong, Yangxun Pan, +22

Proceedings of the National Academy of Sciences

The Role of eIF4E in Response and Acquired Resistance to Vemurafenib in Melanoma

Zhan Yao, Michael S. Dahabieh, Arjuna Rajakumar, +9

Journal of Investigative Dermatology

Acquired ResistanceMedicineMelanomaImmunologyPharmacology +6