Prostaglandin E2-Induced Cell Death is Mediated by Activation of EP2 Receptors in Motor Neuron-like NSC-34 Cells

Hiroko Miyagishi, Yasuhiro Kosuge, Yuki Yoneoka, +6

Journal of Pharmacological Sciences

Protective effect of S-allyl-l-cysteine against endoplasmic reticulum stress-induced neuronal death is mediated by inhibition of calpain

Toru Imai, Yasuhiro Kosuge, Kaori Endo‐Umeda, +4

Amino Acids

Signal TransductionMedicineApoptosisCell DeathNeuropharmacology +8

Prostaglandin E2 facilitates neurite outgrowth in a motor neuron-like cell line, NSC-34

Hiroshi Nango, Yasuhiro Kosuge, Hiroko Miyagishi, +3

Journal of Pharmacological Sciences

Pge2 InducesNeurotransmissionCellular PhysiologySocial SciencesNeuroregeneration +18

Expression of Microsomal Prostaglandin E Synthase-1 in the Spinal Cord in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Hiroko Miyagishi, Yasuhiro Kosuge, Kumiko Ishige, +1

Journal of Pharmacological Sciences

Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral Sclerosis

Hiroko Miyagishi, Yasuhiro Kosuge, Ayumi Takano, +8

Cellular and Molecular Neurobiology

Amyotrophic Lateral SclerosisDisease ProgressionBiochemistrySpinal AstrocytesNeurochemical Biomarkers +5

Generation of Cellular Reactive Oxygen Species by Activation of the EP2 Receptor Contributes to Prostaglandin E2-Induced Cytotoxicity in Motor Neuron-Like NSC-34 Cells

Yasuhiro Kosuge, Hiroshi Nango, Hiroki Kasai, +6

Oxidative Medicine and Cellular Longevity

Lipid PeroxidationApoptosisCell DeathRedox BiologyCellular Physiology +19

Neuroprotective effect of yokukansan against cytotoxicity induced by corticosterone on mouse hippocampal neurons

Yoshihiko Nakatani, Minoru Tsuji, Taku Amano, +7

Phytomedicine

InflammationMouse Hippocampal NeuronsMedicineImmunologyCell Death +11

Yokukansan, a traditional Japanese herbal medicine, enhances the anxiolytic effect of fluvoxamine and reduces cortical 5-HT 2A receptor expression in mice

Rintaro Ohno, Hiroko Miyagishi, Minoru Tsuji, +4

Journal of Ethnopharmacology

Traditional Chinese MedicineMedicineHerbal MedicineHerb-drug InteractionAnxiolytic Effect +4

Protective action of mithramycin against neurodegeneration and impairment of synaptic plasticity in the hippocampal CA1 area after transient global ischemia

Nobuhiro Osada, Yasuhiro Kosuge, Sayuri Oguchi, +3

Neurochemistry International

Transient Global IschemiaSynaptic PlasticityNeurodegenerative DiseasesProtective ActionNeurophysiology +10

Characterization of Motor Neuron Prostaglandin E2 EP3 Receptor Isoform in a Mouse Model of Amyotrophic Lateral Sclerosis

Yasuhiro Kosuge, Hiroko Miyagishi, Takashi Shinomiya, +7

Biological and Pharmaceutical Bulletin