Robert I. Higuchi

Optimized arylomycins are a new class of Gram-negative antibiotics

Peter A. Smith, Michael F. T. Koehler, Hany S. Girgis et al. · Nature · 2018 · 348 citations

Antibiotics, Medicine, New Class +6

Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-<i>g</i>]quinolines

Lawrence G. Hamann, Robert I. Higuchi, Lin Zhi et al. · Journal of Medicinal Chemistry · 1998 · 142 citations · Full text

Pharmacotherapy, Pharmaceutical Chemistry, Molecular Pharmacology +16

On the Diastereoselectivity of Intramolecular Pd-Catalyzed TMM Cycloadditions. An Asymmetric Synthesis of the Perhydroazulene (−)-Isoclavukerin A

Barry M. Trost, Robert I. Higuchi · Journal of the American Chemical Society · 1996 · 58 citations

Asymmetric Catalysis, Derivatives, Natural Sciences +10

4-Alkyl- and 3,4-dialkyl-1,2,3,4,-tetrahydro-8-pyridono[5,6-g]quinolines: Potent, nonsteroidal androgen receptor agonists

Robert I. Higuchi, James P. Edwards, Thomas R. Caferro et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 52 citations · Full text

Medicinal Chemistry, Medicine, Hormonal Receptor +5

Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)-2H-pyrano[3,2-g]quinolin-2-one

James P. Edwards, Robert I. Higuchi, David T. Winn et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 48 citations · Full text

Medicine, Hormonal Receptor, Pharmacotherapy +4