Joshua D. Parsels

Mechanism of Radiosensitization by the Chk1/2 Inhibitor AZD7762 Involves Abrogation of the G2 Checkpoint and Inhibition of Homologous Recombinational DNA Repair

Meredith A. Morgan, Leslie A. Parsels, Lili Zhao et al. · Cancer Research · 2010 · 299 citations · Full text

Medicine, Oncology, Pharmacology +13

Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy

Qiang Zhang, Michael D. Green, Xueting Lang et al. · Cancer Research · 2019 · 243 citations · Full text

Medicine, Immunology, Oncology +17

Dose Escalation Trial of the Wee1 Inhibitor Adavosertib (AZD1775) in Combination With Gemcitabine and Radiation for Patients With Locally Advanced Pancreatic Cancer

Kyle C. Cuneo, Meredith A. Morgan, Vaibhav Sahai et al. · Journal of Clinical Oncology · 2019 · 201 citations · Full text

Medicine, Oncology, Pharmacology +14

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

Leslie A. Parsels, Meredith A. Morgan, Daria M. Tanska et al. · Molecular Cancer Therapeutics · 2009 · 144 citations · Full text

Medicine, Oncology, Pharmacology +17

PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors

Leslie A. Parsels, David Karnak, Joshua D. Parsels et al. · Molecular Cancer Research · 2017 · 140 citations · Full text

Life Sciences, Molecular Biology, Oncology +16