Megan Leander

Functional plasticity and evolutionary adaptation of allosteric regulation

Megan Leander, Yuchen Yuan, Anthony Meger et al. · Proceedings of the National Academy of Sciences · 2020 · 107 citations · Full text

Mapping the functional landscape of the receptor binding domain of T7 bacteriophage by deep mutational scanning

Phil Huss, Anthony Meger, Megan Leander et al. · eLife · 2021 · 67 citations · Full text

Deep mutational scanning and machine learning reveal structural and molecular rules governing allosteric hotspots in homologous proteins

Megan Leander, Zhuang Liu, Qiang Cui et al. · eLife · 2022 · 47 citations · Full text

Cardiac Contractility Structure-Activity Relationship and Ligand-Receptor Interactions; the Discovery Of Unique and Novel Molecular Switches in Myosuppressin Signaling

Megan Leander, Chloe Bass, Kathryn Marchetti et al. · PLoS ONE · 2015 · 15 citations · Full text

Cardiac Muscle, Molecular Biology, Drmms-drmms-r2 Contacts +23

Conserved molecular switch interactions in modeled cardioactive RF-NH2 peptide receptors: Ligand binding and activation

Monica Rasmussen, Megan Leander, Sheila Ons et al. · Peptides · 2015 · 14 citations

Molecular Physiology, Signal Transduction, Biochemistry +10