Thomas Nicola

First Scale-Up to Production Scale of a Ring Closing Metathesis Reaction Forming a 15-Membered Macrocycle as a Precursor of an Active Pharmaceutical Ingredient

Thomas Nicola, Michael Brenner, Kai Donsbach et al. · Organic Process Research & Development · 2005 · 172 citations

Combinatorial Chemistry, Active Pharmaceutical Ingredient, Bioorganic Chemistry +19

Efficient Large-Scale Synthesis of BILN 2061, a Potent HCV Protease Inhibitor, by a Convergent Approach Based on Ring-Closing Metathesis

Nathan K. Yee, Vittorio Farina, Ioannis N. Houpis et al. · The Journal of Organic Chemistry · 2006 · 159 citations

Combinatorial Chemistry, Bioorganic Chemistry, Engineering +18

Anionic Cyclizations of Pentynones and Hexynones: Access to Furan and Pyran Derivatives

Thomas Nicola, Ralf Vieser, Wolfgang Eberbach · European Journal of Organic Chemistry · 2000 · 19 citations

Engineering, Organic Chemistry, Chemistry +17

Asymmetric Synthesis of LFA-1 Inhibitor BIRT2584 on Metric Ton Scale

Xiao‐jun Wang, Rogelio P. Frutos, Li Zhang et al. · Organic Process Research & Development · 2011 · 14 citations

Bioorganic Chemistry, Metric Ton Scale, Organic Chemistry +18