Jade Bath

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

Barbara H. Stokes, Satish K. Dhingra, Kelly Rubiano et al. · eLife · 2021 · 175 citations · Full text

Life Sciences, Genetics, Infectious Diseases +16

Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study

Alejandro Llanos‐Cuentas, Martín Casapía, Raúl Chuquiyauri et al. · The Lancet Infectious Diseases · 2018 · 144 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +15

Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in <i>Plasmodium falciparum</i> that Confer <i>in Vitro</i> Resistance to the Clinical Candidate DSM265

John White, Satish K. Dhingra, Xiaoyi Deng et al. · ACS Infectious Diseases · 2018 · 59 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +16

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to <i>Plasmodium falciparum</i> parasite resistance

James M. Murithi, Cécile Pascal, Jade Bath et al. · Science Translational Medicine · 2021 · 50 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

Michael Palmer, Xiaoyi Deng, Shawn Watts et al. · Journal of Medicinal Chemistry · 2021 · 46 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17