Yu‐Kai Chao

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

Susanne Gerndt, Cheng‐Chang Chen, Yu‐Kai Chao et al. · eLife · 2020 · 150 citations · Full text

Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells

Ong Nam Phuong Nguyen, Christian Grimm, Lina S. Schneider et al. · Cancer Research · 2017 · 126 citations

Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes

Cheng‐Chang Chen, Chunlei Cang, Stefanie Fenske et al. · Nature Protocols · 2017 · 97 citations

Patch-clamp Technique, Endocytic Pathway, Molecular Biology +9

TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms

Yu‐Kai Chao, Verena Schludi, Cheng‐Chang Chen et al. · Proceedings of the National Academy of Sciences · 2017 · 71 citations · Full text

Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2

Ponsawan Netcharoensirisuk, Carla Abrahamian, Rachel Tang et al. · Scientific Reports · 2021 · 61 citations · Full text