Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function

Kazuyuki Takata, Tatsuya Kozaki, Christopher Lee, +39

Immunity

Macrophage BiologyInduced Pluripotent Stem CellMedicineAdult Stem CellImmunology +6

Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2

Naomi McGovern, Amanda Shin, Gillian Low, +35

Nature

Autoimmune DiseaseImmune Cell DevelopmentT-regulatory CellImmunologyAutoimmunity +4

Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2–P2X7 pathway

Sandra Hubert, Björn Rissiek, Katjana Klages, +7

The Journal of Experimental Medicine

NAD+ Released during Inflammation Participates in T Cell Homeostasis by Inducing ART2-Mediated Death of Naive T Cells In Vivo

Sahil Adriouch, Sandra Hubert, Sèverine Pechberty, +3

The Journal of Immunology

A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome

Perrine Soret, Christelle Le Dantec, Emiko Desvaux, +133

Nature Communications

A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

Baptiste Janela, Amit A. Patel, Mai Chan Lau, +27

Immunity

InflammationBacterial InfectionsMicrobial DiseaseMicrobial PathogensGranulocyte +12

Melanoma-initiating cells exploit M2 macrophage TGFβ and arginase pathway for survival and proliferation

Muly Tham, Kar Wai Tan, Jo Keeble, +8

Oncotarget

ImmunologyCell DeathCell ProliferationImmunotherapeuticsCancer Biology +15

Metformin Monotherapy Downregulates Diabetes-Associated Inflammatory Status and Impacts on Mortality

Anteneh Mehari Tizazu, Ma Shwe Zin Nyunt, Olivier Cexus, +11

Frontiers in Physiology

InflammationMetabolic SyndromeMetformin MonotherapyDiabetes ManagementAging +10

Industrializing AI-powered drug discovery: lessons learned from the <i>Patrimony</i> computing platform

Mickaël Guedj, Jack Swindle, Antoine Hamon, +11

Expert Opinion on Drug Discovery

Network-based repurposing identifies anti-alarmins as drug candidates to control severe lung inflammation in COVID-19

Emiko Desvaux, Antoine Hamon, Sandra Hubert, +11

PLoS ONE

Worldwide Collective ImmunityInflammatory Lung DiseaseLung InflammationImmunologyImmunologic Mechanism +21