Wei Shen Aik

Structure of human RNA <i>N</i>6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation

Wei Shen Aik, John S. Scotti, Hwanho Choi et al. · Nucleic Acids Research · 2014 · 246 citations · Full text

Structures of Human ALKBH5 Demethylase Reveal a Unique Binding Mode for Specific Single-stranded N6-Methyladenosine RNA Demethylation

Chao Xu, Ke Liu, W. Tempel et al. · Journal of Biological Chemistry · 2014 · 185 citations · Full text

Nucleic Acid Chemistry, Alkb Family, Biochemistry +14

5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation

Richard J. Hopkinson, Anthony Tumber, Clarence Yapp et al. · Chemical Science · 2013 · 163 citations · Full text

Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO)

Wei Shen Aik, Marina Demetriades, Muhammad K. K. Hamdan et al. · Journal of Medicinal Chemistry · 2013 · 155 citations · Full text

Drug Target, Molecular Biology, Chemical Biology +22

Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition

Jürgen Brem, Sander S. van Berkel, Wei Shen Aik et al. · Nature Chemistry · 2014 · 116 citations

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Chemistry +9