Reece M. Hoffmann

(<i>S</i>)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase

Denise Rageot, Thomas Bohnacker, Erhan Keleş et al. · Journal of Medicinal Chemistry · 2019 · 54 citations · Full text

Compound 6, Brain Penetration, Cellular Pharmacology +25

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5

Meredith L. Jenkins, Jean Piero Margaria, Jordan TB Stariha et al. · Nature Communications · 2018 · 48 citations · Full text

Crystal structure of a lipin/Pah phosphatidic acid phosphatase

Valerie I. Khayyo, Reece M. Hoffmann, Huan Wang et al. · Nature Communications · 2020 · 46 citations · Full text

Probing Protein–Membrane Interactions and Dynamics Using Hydrogen–Deuterium Exchange Mass Spectrometry (HDX-MS)

Jordan TB Stariha, Reece M. Hoffmann, David Hamelin et al. · Methods in molecular biology · 2021 · 45 citations

Proteinlipid Interaction, Biochemistry, Natural Sciences +10

Characterization of the c10orf76‐PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication

Jacob A. McPhail, Heyrhyoung Lyoo, Joshua G. Pemberton et al. · EMBO Reports · 2019 · 42 citations · Full text

Virus Structure, Viral Replication, Golgi Pi4p Levels +10