Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling

Ultan McDermott, Sreenath V. Sharma, Lori Dowell, +22

Proceedings of the National Academy of Sciences

EngineeringKinase InhibitorsCancer BiologyTumor BiologyTumor Heterogeneity +16

JunD Mediates Survival Signaling by the JNK Signal Transduction Pathway

Jennifer Lamb, Juan‐José Ventura, Patricia Hess, +2

Molecular Cell

Signal TransductionSignaling PathwayCell RegulationGene ExpressionGene Regulation +7

Resemblance of actin-binding protein/actin gels to covalently crosslinked networks

Paul A. Janmey, Søren Hvidt, Jennifer Lamb, +1

Nature

Protein AssemblyCross-linkProtein FoldingNatural SciencesMolecular Biology +6

Phosphoinositide-binding peptides derived from the sequences of gelsolin and villin.

Paul A. Janmey, Jennifer Lamb, Philip G. Allen, +1

Journal of Biological Chemistry

The T790M “gatekeeper” mutation in <i>EGFR</i> mediates resistance to low concentrations of an irreversible EGFR inhibitor

Nadia Godin-Heymann, Lindsey Ulkus, Brian W. Brannigan, +5

Molecular Cancer Therapeutics

c-Jun NH ₂ -Terminal Kinase Is Essential for the Regulation of AP-1 by Tumor Necrosis Factor

Juan‐José Ventura, Norman J. Kennedy, Jennifer Lamb, +2

Molecular and Cellular Biology

Effect of ATP on actin filament stiffness

Paul A. Janmey, Søren Hvidt, George Oster, +3

Nature

MechanobiologyEngineeringBiomechanicsPhysiologyCytoskeleton +8

Phosphorylation of the desmoplakin COOH terminus negatively regulates its interaction with keratin intermediate filament networks.

Thaddeus S. Stappenbeck, Jennifer Lamb, Connie M. Corcoran, +1

Journal of Biological Chemistry

Desmoplakin Cooh TerminusMolecular RegulationMolecular BiologySerine 23Cytoskeleton +15

Modulation of gelsolin function. Activation at low pH overrides Ca2+ requirement.

Jennifer Lamb, Philip G. Allen, Bertrand Tuan, +1

Journal of Biological Chemistry

CytoskeletonCellular PhysiologyLow PhCa2+ TransientsBiophysics +16

Viscoelasticity of F-actin and F-actin/gelsolin complexes

Paul A. Janmey, Joyce Peetermans, Jennifer Lamb, +2

Biochemistry

Shear StrainEngineeringMicrorheologyCytoskeletonBiomedical Engineering +16