Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease

Britta George, Rakesh Kumar Verma, Abdulsalam A. Soofi, +13

Journal of Clinical Investigation

EngineeringHealthy Podocyte FootCell AdhesionCytoskeletonPodocyte Foot Process +24

5-HT2B antagonism arrests non-canonical TGF-β1-induced valvular myofibroblast differentiation

Joshua D. Hutcheson, Larisa Ryzhova, Vincent Setola, +1

Journal of Molecular and Cellular Cardiology

5-Ht2b AntagonismFibroblast Growth FactorMedicineCell BiologyCell Signaling

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation

Channabasavaiah B. Gurumurthy, Aidan R. O’Brien, Rolen M. Quadros, +109

Genome biology

Cadherin-11 Regulates Cell–Cell Tension Necessary for Calcific Nodule Formation by Valvular Myofibroblasts

Joshua D. Hutcheson, Joseph Chen, Mary Kathryn Sewell-Loftin, +4

Arteriosclerosis Thrombosis and Vascular Biology

Dynamics and Mechanism of p130Cas Localization to Focal Adhesions

Dominique M. Donato, Larisa Ryzhova, Leslie M. Meenderink, +2

Journal of Biological Chemistry

MicroscopyCell AdhesionMolecular BiologyCellular PhysiologyMatrix Biology +15

P130Cas Src-Binding and Substrate Domains Have Distinct Roles in Sustaining Focal Adhesion Disassembly and Promoting Cell Migration

Leslie M. Meenderink, Larisa Ryzhova, Dominique M. Donato, +3

PLoS ONE

Notch1 Mutation Leads to Valvular Calcification Through Enhanced Myofibroblast Mechanotransduction

Joseph Chen, Larisa Ryzhova, Mary Kathryn Sewell-Loftin, +4

Arteriosclerosis Thrombosis and Vascular Biology

Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension

James West, Erica J. Carrier, Nathaniel Bloodworth, +7

PLoS ONE

HypertensionBmpr2 Mutant MiceImmunologyPulmonary HypertensionSerotonergic Anorexigens +14

Cadherin-11 as a regulator of valve myofibroblast mechanobiology

Meghan Bowler, Matthew R. Bersi, Larisa Ryzhova, +3

American Journal of Physiology-Heart and Circulatory Physiology

Pathological Conversion of Mouse Perivascular Adipose Tissue by Notch Activation

Joshua M. Boucher, Larisa Ryzhova, Anne Harrington, +8

Arteriosclerosis Thrombosis and Vascular Biology