Activation of miR-34a/SIRT1/p53 signaling contributes to cochlear hair cell apoptosis: implications for age-related hearing loss

Hao Xiong, Jiaqi Pang, Haidi Yang, +9

Neurobiology of Aging

Age-related Hearing LossDevelopmental BiologyHealth SciencesLongevityHair Cell Apoptosis +10

Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of mitophagy and mitochondrial biogenesis

Hao Xiong, Suijun Chen, Lan Lai, +6

Neurobiology of Aging

Age-related Hearing LossMitophagyDevelopmental BiologyMitochondrial BiogenesisGenetics +11

SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy

Jiaqi Pang, Hao Xiong, Yongkang Ou, +10

Neurobiology of Aging

Cell AutophagyMitophagyAutophagyAudiologyCell Death +9

Activation of miR-34a impairs autophagic flux and promotes cochlear cell death via repressing ATG9A: implications for age-related hearing loss

Jiaqi Pang, Hao Xiong, Peiliang Lin, +8

Cell Death and Disease

SIRT1 expression in the cochlea and auditory cortex of a mouse model of age-related hearing loss

Hao Xiong, Min Dai, Yongkang Ou, +11

Experimental Gerontology

Auditory ProcessingDevelopmental BiologyHealth SciencesAuditory CortexAudiology +11

Circulating miR-34a levels correlate with age-related hearing loss in mice and humans

Jiaqi Pang, Hao Xiong, Haidi Yang, +8

Experimental Gerontology

Health SciencesPhysiologyAudiologyAuditory PhysiologyMir-34a Levels +9

High-dose PMA with RANKL and MCSF induces THP-1 cell differentiation into human functional osteoclasts in vitro

Zhuo Hao Li, Yu Si, Guo Liang Xu, +5

Molecular Medicine Reports

Thp-1 Cell DifferentiationImmunologyCell DeathOrthopaedic SurgeryCellular Physiology +15

Sirtuin 1 and Autophagy Attenuate Cisplatin-Induced Hair Cell Death in the Mouse Cochlea and Zebrafish Lateral Line

Jiaqi Pang, Hao Xiong, Ting Zhan, +17

Frontiers in Cellular Neuroscience

Inhibition of DRP-1-Dependent Mitophagy Promotes Cochlea Hair Cell Senescence and Exacerbates Age-Related Hearing Loss

Hanqing Lin, Hao Xiong, Zhongwu Su, +6

Frontiers in Cellular Neuroscience

Nrf2 activation protects auditory hair cells from cisplatin-induced ototoxicity independent on mitochondrial ROS production

Weijian Zhang, Hao Xiong, Jiaqi Pang, +7

Toxicology Letters

Mitochondrial FunctionCell DeathMolecular BiologyNrf2 ActivationMitochondrial Ros Production +6