Nathan K. Layle

Synthesis, Chemical Characterization, and μ-Opioid Receptor Activity Assessment of the Emerging Group of “Nitazene” 2-Benzylbenzimidazole Synthetic Opioids

Marthe M. Vandeputte, Katleen Van Uytfanghe, Nathan K. Layle et al. · ACS Chemical Neuroscience · 2021 · 136 citations · Full text

Respiratory depressant effects of fentanyl analogs are opioid receptor-mediated

Neil B. Varshneya, Sherif H. Hassanien, Melissa C. Holt et al. · Biochemical Pharmacology · 2021 · 54 citations · Full text

Opioid Epidemic, Fentanyl, Addiction +8

Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression

Neil B. Varshneya, Sherif H. Hassanien, Melissa C. Holt et al. · Pharmacology Biochemistry and Behavior · 2023 · 24 citations · Full text

Health Sciences, Functional Selectivity, Pain Medicine +11

Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice

Marthe M. Vandeputte, Grant C. Glatfelter, Donna Walther et al. · Pharmacological Research · 2024 · 13 citations · Full text