Jackie Shang

(2<i>S</i>,3<i>S</i>)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-<i>N,N</i>-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-<i>a</i>]- pyridin-6-ylphenyl)butanamide:  A Selective α-Amino Amide Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Scott D. Edmondson, Anthony Mastracchio, Robert J. Mathvink et al. · Journal of Medicinal Chemistry · 2006 · 121 citations · Full text

Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors

Scott D. Edmondson, Lan Wei, Jinyou Xu et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 106 citations · Full text

Medicinal Chemistry, Bioorganic Chemistry, Biochemistry +10

Discovery of a Novel Glucagon Receptor Antagonist<i>N</i>-[(4-{(1<i>S</i>)-1-[3-(3, 5-Dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1<i>H</i>-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the Treatment of Type II Diabetes

Yusheng Xiong, Jian Guo, Mari R. Candelore et al. · Journal of Medicinal Chemistry · 2012 · 86 citations · Full text

Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure–Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program

Ting Zhang, Yong Liu, Xianshu Yang et al. · Journal of Medicinal Chemistry · 2016 · 20 citations · Full text

Drug Target, Hit Identification, Novel Approach +18

Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester

Jackie Shang, Richard A. Tschirret-Guth, Mark T. Cancilla et al. · Chemical Research in Toxicology · 2019 · 19 citations