YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage

Eric Ciamporcero, He Shen, Swathi Ramakrishnan, +12

Oncogene

UrologyGenitourinary CancerTumor SuppressorMedicineCell Biology +3

Crosstalk between Nrf2 and YAP contributes to maintaining the antioxidant potential and chemoresistance in bladder cancer

Eric Ciamporcero, Martina Daga, Stefania Pizzimenti, +7

Free Radical Biology and Medicine

Reductive StressTumor BiologyAntioxidant PotentialMedicinePharmacology +7

GSH-targeted nanosponges increase doxorubicin-induced toxicity “in vitro” and “in vivo” in cancer cells with high antioxidant defenses

Martina Daga, Chiara Ullio, Monica Argenziano, +11

Free Radical Biology and Medicine

NanomedicineDrug TargetingMedicineHigh Antioxidant DefensesCancer Cell Biology +7

KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease

Cinzia Antognelli, Eliana Trapani, Simona Delle Monache, +10

Free Radical Biology and Medicine

Ailanthone inhibits cell growth and migration of cisplatin resistant bladder cancer cells through down-regulation of Nrf2, YAP, and c-Myc expression.

Martina Daga, Stefania Pizzimenti, Chiara Dianzani, +7

Phytomedicine

UrologyOncologyGenitourinary CancerC-myc ExpressionMedicine +7

Glutathione-responsive cyclodextrin-nanosponges as drug delivery systems for doxorubicin: Evaluation of toxicity and transport mechanisms in the liver

Martina Daga, Inge A.M. de Graaf, Monica Argenziano, +10

Toxicology in Vitro

NanomedicineEngineeringMedicineLiver PhysiologyCyclodextrin Production +9

Novel tetrahydroacridine derivatives with iodobenzoic moieties induce G0/G1 cell cycle arrest and apoptosis in A549 non-small lung cancer and HT-29 colorectal cancer cells

Małgorzata Girek, Karol Kamil Kłosiński, Bartłomiej Grobelski, +7

Molecular and Cellular Biochemistry

Post-translational inhibition of YAP oncogene expression by 4-hydroxynonenal in bladder cancer cells

Marie Angèle Cucci, Alessandra Compagnone, Martina Daga, +12

Free Radical Biology and Medicine

Yap Oncogene ExpressionPost-translational InhibitionMedicineOncogenic AgentPharmacology +6

The inclusion complex of 4-hydroxynonenal with a polymeric derivative of β-cyclodextrin enhances the antitumoral efficacy of the aldehyde in several tumor cell lines and in a three-dimensional human melanoma model

Stefania Pizzimenti, Eric Ciamporcero, Piergiorgio Pettazzoni, +14

Free Radical Biology and Medicine

Tumor BiologyMedicinal ChemistryInclusion ComplexMedicineCyclodextrin Production +10

Generation of Adducts of 4-Hydroxy-2-nonenal with Heat Shock 60 kDa Protein 1 in Human Promyelocytic HL-60 and Monocytic THP-1 Cell Lines

Alessia Arcaro, Martina Daga, Giovanni Paolo Cetrangolo, +11

Oxidative Medicine and Cellular Longevity