Kang-Jye Chou

Discovery of (<i>S</i>)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1<i>H</i>-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1<i>H</i>)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development

James F. Blake, Michael Burkard, Jocelyn Chan et al. · Journal of Medicinal Chemistry · 2016 · 156 citations · Full text

Erk Kinase Activity, Cellular Pharmacology, Tumor Biology +20

Abstract 526: RMC-9805, a first-in-class, mutant-selective, covalent and oral KRASG12D(ON) inhibitor that induces apoptosis and drives tumor regression in preclinical models of KRASG12D cancers

Lingyan Jiang, Marie Ménard, Caroline E. Weller et al. · Cancer Research · 2023 · 61 citations

Oral Krasg12d, Tumor Biology, Krasg12d Nsclc +13

DISTRIBUTION OF ANTIHISTAMINES INTO THE CSF FOLLOWING INTRANASAL DELIVERY

Kang-Jye Chou, Maureen D. Donovan · Biopharmaceutics & Drug Disposition · 1997 · 58 citations

Pharmacological Study, Drug Disposition, Medicine +13

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy

Jack A. Terrett, Huifen Chen, Daniel G. Shore et al. · Journal of Medicinal Chemistry · 2021 · 49 citations · Full text

Evaluation of Drug Load and Polymer by Using a 96-Well Plate Vacuum Dry System for Amorphous Solid Dispersion Drug Delivery

Po‐Chang Chiang, Yingqing Ran, Kang-Jye Chou et al. · AAPS PharmSciTech · 2012 · 46 citations · Full text

Engineering, Drug Load, Polymer Science +6