Akira Otaka

Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes

Hirokazu Tamamura, Akane Omagari, Shinya Oishi et al. · Bioorganic & Medicinal Chemistry Letters · 2000 · 113 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Copper-Mediated Deprotection of Thiazolidine and Selenazolidine Derivatives Applied to Native Chemical Ligation

Naoto Naruse, Daishiro Kobayashi, Kento Ohkawachi et al. · The Journal of Organic Chemistry · 2019 · 28 citations

Natural Sciences, Biochemistry, Chemistry +7

Asymmetric Synthesis of α‐Amino Phosphonic Acids using Stable Imino Phosphonate as a Universal Precursor

Tsubasa Inokuma, Takuya Sakakibara, Takatoshi Someno et al. · Chemistry - A European Journal · 2019 · 22 citations · Full text

Natural Sciences, Medicinal Chemistry, Biocatalysis +11

Molecular‐Size Reduction of a Potent CXCR4‐Chemokine Antagonist Using Orthogonal Combination of Conformation‐ and Sequence‐Based Libraries

Nobutaka Fujii, Shinya Oishi, Kenichi Hiramatsu et al. · Angewandte Chemie · 2003 · 19 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Traceless synthesis of protein thioesters using enzyme-mediated hydrazinolysis and subsequent self-editing of the cysteinyl prolyl sequence

Chiaki Komiya, Akira Shigenaga, Jun Tsukimoto et al. · Chemical Communications · 2019 · 17 citations · Full text

Life Sciences, Biochemistry, Biotechnology +12